DETAILED NOTES ON 666-15

The large GTPase dynamin is important for clathrin-dependent coated-vesicle development. Dynasore is really a cell-permeable compact molecule that inhibits the GTPase activity of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin. Dynasore was identified inside of a screen of ~16,000 compounds for inhibitors on the dynamin2 GTPase., the dynamin